Biobetters in patients with immune-mediated inflammatory disorders: an international Delphi consensus

D'Amico, Ferdinando, Solitano, Virginia, Aletaha, Daniel, Hart, Ailsa, Magro, Fernando, Selmi, Carlo, Ng, Siew C., Al Awadhi, Sameer, Choy, Ernest ORCID: https://orcid.org/0000-0003-4459-8609, Schulze-Koops, Hendrik, Bossuyt, Peter, Olivera, Pablo A., Kotze, Paulo Gustavo, Ghosh, Subrata, Peyrin-Biroulet, Laurent and Danese, Silvio 2021. Biobetters in patients with immune-mediated inflammatory disorders: an international Delphi consensus. Autoimmunity Reviews 20 (7) , 102849. 10.1016/j.autrev.2021.102849

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Abstract

Several efforts have been made to improve the available therapeutic armamentarium of patients with immune-mediated inflammatory disorders (IMIDs) leading to the development of biobetters. To date, there is no commonly accepted definition of biobetters. Sixteen physicians with expertise in the field of IMIDs from eleven countries attended a virtual international consensus meeting to provide for the first time a definition of biobetter and to identify unmet needs on this topic. Improvements in clinical outcomes and drug pharmacology were considered crucial for the definition of biobetters, while safety profile and patient acceptability were not. In addition, an appropriate balance between clinical outcomes and costs and a shared decision between physicians and patients should guide the decision to use a biobetter. Clinical studies are required to validate the biobetter definition and to investigate their role in the management of patients with IMIDs.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Elsevier
ISSN:	1568-9972
Date of First Compliant Deposit:	18 June 2021
Date of Acceptance:	12 March 2021
Last Modified:	07 Nov 2023 01:54
URI:	https://orca.cardiff.ac.uk/id/eprint/141951

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