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Postural orthostatic tachycardia syndrome: insights into pathogenesis and treatment

Al-Ansari, A. and Robertson, N. P. ORCID: 2021. Postural orthostatic tachycardia syndrome: insights into pathogenesis and treatment. Journal of Neurology 268 (7) , 2616–2618. 10.1007/s00415-021-10649-9

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Postural orthostatic tachycardia syndrome (POTS) is a form of chronic dysautonomia, most commonly seen in women of child-bearing age and often associated with reduced quality of life. Current diagnostic criteria require an increase in heart rate of 30 beats per minute (bpm), or over 120 bpm in the first 10 min of standing, in the absence of orthostatic hypotension, and associated with orthostatic intolerance. Other symptoms suggestive of autoimmune failure include sudomotor dysfunction and gastrointestinal dysmotility. However, the heterogeneity of clinical presentation and uncertainty of pathogenesis, often prompts a search for alternative causes before a diagnosis of POTS, a made.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Additional Information: This article is licensed under a Creative Commons Attribution 4.0 International License
Publisher: Springer
ISSN: 0340-5354
Date of First Compliant Deposit: 12 July 2021
Date of Acceptance: 1 June 2021
Last Modified: 13 May 2023 18:27

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