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Fractional exhaled nitric oxide in preterm-born subjects: a systematic review and meta-analysis

Kotecha, Sarah, Course, Christopher and Kotecha, Sailesh ORCID: 2019. Fractional exhaled nitric oxide in preterm-born subjects: a systematic review and meta-analysis. Presented at: European Respiratory Society International Congress 2018, Paris, France, 15-19 September 2018. European Respiratory Journal. , vol.54 (Supple) European Respiratory Society, 10.1183/13993003.congress-2019.PA1024

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Background: Respiratory symptoms and decreased lung function are reported in preterm-born subjects. In asthma, higher levels of fractional exhaled nitric oxide (FeNO) have been reported in children as a test for eosinophilic airway inflammation. Aims and Objectives: We systematically reviewed and meta-analysed the literature reporting FeNO levels in preterm-born subjects compared to term subjects. Methods: Studies comparing FeNO levels in preterm-born subjects (<37 weeks’ gestation) in childhood and adulthood, with and without CLD, with term-born subjects were identified from 8 databases up to February 2018. Titles and abstracts were independently reviewed for inclusion by 2 reviewers. Data were analysed using Review Manager v5.3. Results: The searches identified 6,042 article titles, of which 183 full articles were screened for inclusion. 19 studies met the inclusion criteria. 17 studies were included in the systematic review; 11 studies were included in a meta-analysis. The mean FeNO concentration difference between the preterm-born (n=640) and term-born group (n=4,005) was -0.74 (95% CI -1.88 to 0.41) ppb. For six studies reporting data on CLD (preterm n=204 and term n=211), the mean difference for FeNO levels was -2.82 (95% CI -5.87 to 0.22) ppb between the preterm-born CLD and term-born groups. Conclusions: The results suggest that preterm born children born with and without CLD have similar FeNO levels to term-born children. An, alternative mechanism to eosinophilic inflammation is likely to be responsible for the symptoms of wheezing and airway obstruction observed in preterm-born subjects.

Item Type: Conference or Workshop Item (Poster)
Date Type: Published Online
Status: Published
Schools: Medicine
Publisher: European Respiratory Society
ISSN: 0903-1936
Last Modified: 02 Mar 2024 02:07

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