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The role and uses of antibodies in COVID-19 infections: a living review

Scourfield, D. Oliver, Reed, Sophie G., Quastel, Max, Alderson, Jennifer, Bart, Valentina M. T., Teijeira Crespo, Alicia, Jones, Ruth, Pring, Ellie, Richter, Felix Clemens, Ahern, David J., Almuttaqi, Hannah, Alonzi, Dominic S., Alrubayyi, Aljawharah, Alsaleh, Ghada, Bart, Valentina M. T., Batchelor, Vicky, Bayliss, Rebecca, Berthold, Dorothée L., Bezbradica, Jelena S, Bharuchq, Tehmina, Borrmann, Helene, Borsa, Mariana, Borst, Rowie, Brun, Juliane, Burnell, Stephanie E. A., Capitani, Lorenzo, Cavounidis, Athena, Chapman, Lucy, Chauveau, Anne, Cifuentes, Liliana, Codd, Amy Susan, Compeer, Ewoud Bernardus, Coveney, Clarissa, Cross, Amy, Danielli, Sara, Davies, Luke C, Dendrou, Calliope A., Dimonte, Sandra, Peter Durairaj, Ruban Rex, Dustin, Lynn B., Dyer, Arthur, Fielding, Ceri, Fischer, Fabian, Gallimore, Awen, Galloway, Sarah, Gammage, Anís, Gea-Mallorquí, Ester, Godkin, Andrew, Hanna, Stephanie Jean, Heuberger, Cornelia, Hulin-Curtis, Sarah, Issa, Fadi, Jones, Emma, Jones, Ruth, Ladell, Kristin, Lauder, Sarah N., Liddiard, Kate, Ligoxygakis, Petros, Lu, Fangfang, MacLachlan, Bruce, Maleki-Toyserkani, Shayda, Mann, Elizabeth H., Marzeda, Anna M., James Matthews, Reginald, Mazet, Julie M., Milicic, Anita, Mitchell, Emma, Moon, Owen, Nguyen, Van Dien, O'Hanlon, Miriam, Eléonore Pavillet, Clara, Peppa, Dimitra, Pires, Ana, Pring, Eleanor, Quastel, Max, Reed, Sophie, Rehwinkel, Jan, Richmond, Niamh, Richter, Felix Clemens, Robinson, Alice J. B., Rodrigues, Patrícia R. S., Sabberwal, Pragati, Sami, Arvind, Peres, Raphael Sanches, Sattentau, Quentin, Schonfeldova, Barbora, Scourfield, David Oliver, Selvakumar, Tharini A., Shepherd, Freya R., Shorten, Cariad, Simon, Anna Katharina, Smith, Adrian L., Crespo, Alicia Teijeira, Tellier, Michael, Thornton, Emily, Uhl, Lion F. K., van Grinsven, Erinke, Wann, Angus K. T., Williams, Richard, Wilson, Joseph D., Zhou, Dingxi, Zhu, Zihan and Burnell, Stephanie E. A. 2021. The role and uses of antibodies in COVID-19 infections: a living review. Oxford Open Immunology 2 (1) , iqab003. 10.1093/oxfimm/iqab003

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Abstract

Coronavirus disease 2019 has generated a rapidly evolving field of research, with the global scientific community striving for solutions to the current pandemic. Characterizing humoral responses towards SARS-CoV-2, as well as closely related strains, will help determine whether antibodies are central to infection control, and aid the design of therapeutics and vaccine candidates. This review outlines the major aspects of SARS-CoV-2-specific antibody research to date, with a focus on the various prophylactic and therapeutic uses of antibodies to alleviate disease in addition to the potential of cross-reactive therapies and the implications of long-term immunity.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Additional Information: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/)
ISSN: 2633-6960
Date of First Compliant Deposit: 16 August 2021
Date of Acceptance: 7 January 2021
Last Modified: 01 Feb 2022 12:47
URI: https://orca.cardiff.ac.uk/id/eprint/143440

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