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Role of adipocyte-derived extracellular vesicles in vascular inflammation

Connolly, Katherine D., Rees, D. Aled and James, Philip E. 2021. Role of adipocyte-derived extracellular vesicles in vascular inflammation. Free Radical Biology and Medicine 172 , pp. 58-64. 10.1016/j.freeradbiomed.2021.04.031
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Abstract

Extracellular vesicles (EVs) are nanometre-sized vesicles released from most cells, including adipocytes. Relatively little is known about adipocyte-derived EVs (ADEVs) in comparison to other EV subtypes, though interest in ADEVs as potential paracrine and endocrine communicators of adipose tissue in obesity is building. Current evidence indicates that ADEVs contribute to the development of adipose tissue dysfunction; a key feature of obese adipose tissue that it is associated with obesity-related comorbidities including cardiovascular disease (CVD). This review summarises our current knowledge of ADEVs in the development of adipose tissue dysfunction and the potential of ADEVs to disrupt redox signalling and exert vascular effects that may exacerbate CVD in obesity.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Publisher: Elsevier
ISSN: 0891-5849
Date of First Compliant Deposit: 17 August 2021
Date of Acceptance: 5 May 2021
Last Modified: 23 Oct 2021 09:28
URI: https://orca.cardiff.ac.uk/id/eprint/143505

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