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Interpretation of vaccine associated neurological adverse events: a methodological and historical review

Cauchi, Marija, Ball, Harriet, Ben-Shlomo, Yoav and Robertson, Neil ORCID: 2022. Interpretation of vaccine associated neurological adverse events: a methodological and historical review. Journal of Neurology 269 , pp. 493-503. 10.1007/s00415-021-10747-8

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As a result of significant recent scientific investment, the range of vaccines available for COVID-19 prevention continues to expand and uptake is increasing globally. Although initial trial safety data have been generally reassuring, a number of adverse events, including vaccine induced thrombosis and thrombocytopenia (VITT), have come to light which have the potential to undermine the success of the vaccination program. However, it can be difficult to interpret available data and put these into context and to communicate this effectively. In this review, we discuss contemporary methodologies employed to investigate possible associations between vaccination and adverse neurological outcomes and why determining causality can be challenging. We demonstrate these issues by discussing relevant historical exemplars and explore the relevance for the current pandemic and vaccination program. We also discuss challenges in understanding and communicating such risks to clinicians and the general population within the context of the ‘infodemic’ facilitated by the Internet and other media.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Additional Information: This article is licensed under a Creative Commons Attribution 4.0 International License
Publisher: Springer
ISSN: 0340-5354
Date of First Compliant Deposit: 1 September 2021
Date of Acceptance: 6 August 2021
Last Modified: 06 May 2023 11:23

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