Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Frailty and cerebrovascular disease: Concepts and clinical implications for stroke medicine

Evans, Nicholas R, Todd, Oliver M, Minhas, Jatinder S, Fearon, Patricia, Harston, George W, Mant, Jonathan, Mead, Gillian, Hewitt, Jonathan ORCID:, Quinn, Terence J and Warburton, Elizabeth A 2022. Frailty and cerebrovascular disease: Concepts and clinical implications for stroke medicine. International Journal of Stroke 17 (3) , pp. 251-259. 10.1177/17474930211034331

[thumbnail of 17474930211034331.pdf] PDF - Published Version
Available under License Creative Commons Attribution.

Download (3MB)


Frailty is a distinctive health state in which the ability of older people to cope with acute stressors is compromised by an increased vulnerability brought by age-associated declines in physiological reserve and function across multiple organ systems. Although closely associated with age, multimorbidity, and disability, frailty is a discrete syndrome that is associated with poorer outcomes across a range of medical conditions. However, its role in cerebrovascular disease and stroke has received limited attention. The estimated rise in the prevalence of frailty associated with changing demographics over the coming decades makes it an important issue for stroke practitioners, cerebrovascular research, clinical service provision, and stroke survivors alike. This review will consider the concept and models of frailty, how frailty is common in cerebrovascular disease, the impact of frailty on stroke risk factors, acute treatments, and rehabilitation, and considerations for future applications in both cerebrovascular clinical and research settings.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Additional Information: This article is distributed under the terms of the Creative Commons Attribution 4.0 License (
Publisher: Wiley
ISSN: 1747-4930
Date of First Compliant Deposit: 15 September 2021
Date of Acceptance: 2 July 2021
Last Modified: 10 Nov 2022 09:44

Citation Data

Cited 6 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item


Downloads per month over past year

View more statistics