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The role of macrophages during zebrafish injury and tissue regeneration under infectious and non-infectious conditions

Bohaud, Candice, Johansen, Matt D., Jorgensen, Christian, Kremer, Laurent, Ipseiz, Natacha and Djouad, Farida 2021. The role of macrophages during zebrafish injury and tissue regeneration under infectious and non-infectious conditions. Frontiers in Immunology 12 , 707856. 10.3389/fimmu.2021.707824

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Abstract

The future of regenerative medicine relies on our understanding of the mechanistic processes that underlie tissue regeneration, highlighting the need for suitable animal models. For many years, zebrafish has been exploited as an adequate model in the field due to their very high regenerative capabilities. In this organism, regeneration of several tissues, including the caudal fin, is dependent on a robust epimorphic regenerative process, typified by the formation of a blastema, consisting of highly proliferative cells that can regenerate and completely grow the lost limb within a few days. Recent studies have also emphasized the crucial role of distinct macrophage subpopulations in tissue regeneration, contributing to the early phases of inflammation and promoting tissue repair and regeneration in late stages once inflammation is resolved. However, while most studies were conducted under non-infectious conditions, this situation does not necessarily reflect all the complexities of the interactions associated with injury often involving entry of pathogenic microorganisms. There is emerging evidence that the presence of infectious pathogens can largely influence and modulate the host immune response and the regenerative processes, which is sometimes more representative of the true complexities underlying regenerative mechanics. Herein, we present the current knowledge regarding the paths involved in the repair of non-infected and infected wounds using the zebrafish model.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Publisher: Frontiers Media
ISSN: 1664-3224
Date of First Compliant Deposit: 16 September 2021
Date of Acceptance: 2 July 2021
Last Modified: 21 Sep 2021 16:00
URI: https://orca.cardiff.ac.uk/id/eprint/144181

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