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Heritability of sleep and its disorders in childhood and adolescence

Lewis, Katie J. S. and Gregory, Alice 2021. Heritability of sleep and its disorders in childhood and adolescence. Current Sleep Medicine Reports 7 , pp. 155-166. 10.1007/s40675-021-00216-z

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Purpose of Review This review summarizes recent literature on the heritability of sleep and sleep disorders in childhood and adolescence. We also identify gaps in the literature and priorities for future research. Recent Findings Findings indicate that age, measurement method, reporter, and timing of sleep measurements can influence heritability estimates. Recent genome-wide association studies (GWAS) have identified differences in the heritability of sleep problems when ancestral differences are considered, but sample sizes are small compared to adult GWAS. Most studies focus on sleep variables in the full range rather than on disorder. Studies using objective measures of sleep typically comprised small samples. Summary Current evidence demonstrates a wide range of heritability estimates across sleep phenotypes in childhood and adolescence, but research in larger samples, particularly using objective sleep measures and GWAS, is needed. Further understanding of environmental mechanisms and the interaction between genes and environment is key for future research.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
National Centre for Mental Health (PNCMH)
Additional Information: This article is licensed under a Creative Commons Attribution 4.0 International License
Publisher: Springer
ISSN: 2198-6401
Date of First Compliant Deposit: 23 September 2021
Date of Acceptance: 7 September 2021
Last Modified: 12 Feb 2022 16:15

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