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Antibody deficiency, chronic lung disease, and comorbid conditions: a case based approach

Petrov, Andrej A., Adatia, Adil, Jolles, Stephen, Nair, Parameswaran, Azar, Antoine and Walter, Jolan E. 2021. Antibody deficiency, chronic lung disease, and comorbid conditions: a case based approach. Journal of Allergy and Clinical Immunology: In Practice 9 (11) , pp. 3899-3908. 10.1016/j.jaip.2021.09.031

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Abstract

New emerging pulmonary phenotypes associated with antibody deficiency, such as neutrophilic asthma, frequent exacerbations of chronic obstructive pulmonary disease, and unexplained interstitial lung disease, particularly in younger adults, are discussed in this review through a case-based approach. Also discussed in similar fashion are antibody deficiency syndromes that lead to end-stage lung disease and the indications for lung transplantation in primary immunodeficiency disease. These challenging cases require timely and individualized strategies for genetic and immunologic diagnosis, decisions about therapeutic approaches, and long-term monitoring.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Elsevier
ISSN: 2213-2198
Date of Acceptance: 22 September 2021
Last Modified: 09 Nov 2021 14:26
URI: https://orca.cardiff.ac.uk/id/eprint/144594

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