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A ball-milling-enabled cross-electrophile coupling

Jones, Andrew C., Nicholson, William I., Leitch, Jamie A. and Browne, Duncan L. ORCID: 2021. A ball-milling-enabled cross-electrophile coupling. Organic Letters 23 (16) , 6337–6341. 10.1021/acs.orglett.1c02096

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The nickel-catalyzed cross-electrophile coupling of aryl halides and alkyl halides enabled by ball-milling is herein described. Under a mechanochemical manifold, the reductive C–C bond formation was achieved in the absence of bulk solvent and air/moisture sensitive setups, in reaction times of 2 h. The mechanical action provided by ball milling permits the use of a range of zinc sources to turnover the nickel catalytic cycle, enabling the synthesis of 28 cross-electrophile coupled products.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Publisher: American Chemical Society
ISSN: 1523-7060
Funders: WEFO and the Leverhulme Trust
Date of First Compliant Deposit: 18 October 2021
Date of Acceptance: 3 August 2021
Last Modified: 08 Nov 2023 13:01

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