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Preventing type 1 diabetes in childhood

Dayan, Colin M., Besser, Rachel E. J., Oram, Richard A., Hagopian, William, Vatish, Manu, Bendor-Samuel, Owen, Snape, Matthew D. and Todd, John A. 2021. Preventing type 1 diabetes in childhood. Science 373 (6554) , pp. 506-510. 10.1126/science.abi4742

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Abstract

Type 1 diabetes (T1D) is an autoimmune disease in which the insulin-producing β cells of the pancreas are destroyed by T lymphocytes. Recent studies have demonstrated that monitoring for pancreatic islet autoantibodies, combined with genetic risk assessment, can identify most children who will develop T1D when they still have sufficient β cell function to control glucose concentrations without the need for insulin. In addition, there has been recent success in secondary prevention using immunotherapy to delay the progression of preclinical disease, and primary prevention approaches to inhibiting the initiating autoimmune process have entered large-scale clinical trials. By changing the focus of T1D management from late diagnosis and insulin replacement to early diagnosis and β cell preservation, we can anticipate a future without the need for daily insulin injections for children with T1D.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: American Association for the Advancement of Science
ISSN: 0036-8075
Date of First Compliant Deposit: 27 October 2021
Date of Acceptance: 11 March 2021
Last Modified: 01 Nov 2021 18:57
URI: https://orca.cardiff.ac.uk/id/eprint/145105

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