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Exciting new tools for studying TREM2 in dementia

Menzies, Georgina E. ORCID: and Torvell, Megan 2021. Exciting new tools for studying TREM2 in dementia. Structure 29 (11) , pp. 1215-1216. 10.1016/j.str.2021.10.009

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TREM2 has long been implicated as an Alzheimer’s disease (AD) risk gene. In this issue of Structure, Szykowska et al., 2021 generate antibody single-chain variable fragments (scFvs) to the immunoglobulin(Ig)-like domain of human TREM2. They present two co-crystalized structures and characterize the functional impact of these scFvs on TREM2.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Elsevier
ISSN: 0969-2126
Last Modified: 29 Nov 2022 10:02

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