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Targeting hyaluronic acid and peritoneal dissemination in colorectal cancer

Soliman, Faris, Ye, Lin, Jiang, Wenguo and Hargest, Rachel 2022. Targeting hyaluronic acid and peritoneal dissemination in colorectal cancer. Clinical Colorectal Cancer 21 (2) , e126-e134. 10.1016/j.clcc.2021.11.008
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Peritoneal metastasis (PM) from colorectal cancer (CRC) carries a significant mortality rate for patients and treatment is challenging. The development of PM is a multistep process involving detachment, adhesion, invasion and colonisation of the peritoneal cavity. Cytoreductive surgery and HIPEC (hyperthermic intraperitoneal chemotherapy) for PM from CRC has some benefit but overall survival is poor and recurrence rates are high. Treatments to prevent the development of peritoneal metastasis could have the potential to improve CRC survival and disease-free outcomes. The ability of cancer cells to invade the peritoneum and become established as metastatic tumours is influenced by a multifactorial process. Hyaluronic acid (HA) has been shown to coat the mesothelial cells of the peritoneum and has been demonstrated to be utilised in various malignancies as part of the metastatic process in peritoneal dissemination. CD44, RHAMM (CD168) and ICAM-1 have all been shown to be binding partners for HA. Targeting HA-mediated binding may prevent adhesion to distant sites within the peritoneum through suppression of interaction of these molecules. Here we review the current literature and discuss key molecules involved with PM dissemination, with the potential to target these mechanisms in the delivery of future treatments.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Elsevier
ISSN: 1533-0028
Date of First Compliant Deposit: 29 November 2021
Date of Acceptance: 22 November 2021
Last Modified: 09 Jun 2022 16:21

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