Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

Bentley, Amy R., Sung, Yun J., Brown, Michael R., Winkler, Thomas W., Kraja, Aldi T., Ntalla, Ioanna, Schwander, Karen, Chasman, Daniel I., Lim, Elise, Deng, Xuan, Guo, Xiuqing, Liu, Jingmin, Lu, Yingchang, Cheng, Ching-Yu, Sim, Xueling, Vojinovic, Dina, Huffman, Jennifer E., Musani, Solomon K., Li, Changwei, Feitosa, Mary F., Richard, Melissa A., Noordam, Raymond, Baker, Jenna, Chen, Guanjie, Aschard, Hugues, Bartz, Traci M., Ding, Jingzhong, Dorajoo, Rajkumar, Manning, Alisa K., Rankinen, Tuomo, Smith, Albert V., Tajuddin, Salman M., Zhao, Wei, Graff, Mariaelisa, Alver, Maris, Boissel, Mathilde, Chai, Jin Fang, Chen, Xu, Divers, Jasmin, Evangelou, Evangelos, Gao, Chuan, Goel, Anuj, Hagemeijer, Yanick, Harris, Sarah E., Hartwig, Fernando P., He, Meian, Horimoto, Andrea R. V. R., Hsu, Fang-Chi, Hung, Yi-Jen, Jackson, Anne U., Kasturiratne, Anuradhani, Komulainen, Pirjo, Kuhnel, Brigitte, Leander, Karin, Lin, Keng-Hung, Luan, Jian?an, Lyytikainen, Leo-Pekka, Matoba, Nana, Nolte, Ilja M., Pietzner, Maik, Prins, Bram, Riaz, Muhammad ORCID: https://orcid.org/0000-0002-5512-1745, Robino, Antonietta, Said, M. Abdullah, Schupf, Nicole, Scott, Robert A., Sofer, Tamar and Stancakova, Alena 2019. Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. Nature Genetics 51 (4) , pp. 636-648. 10.1038/s41588-019-0378-y

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Abstract

The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene–smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Nature Research
ISSN:	1061-4036
Date of Acceptance:	7 February 2019
Last Modified:	10 Nov 2022 10:10
URI:	https://orca.cardiff.ac.uk/id/eprint/145904

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