Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Observational study to estimate the proportion of surgical site infection following excision of ulcerated skin tumours (OASIS study)

Abbott, R. A., Cordaro, A., Lloyd, B., Cannings-John, R., Wootton, M., Kirby, N., Pickles, T., McQueen, A., Westmoreland, M., Ziaj, S., Martin-Clavijo, A., Wernham, A., Matin, R. and Thomas-Jones, E. 2021. Observational study to estimate the proportion of surgical site infection following excision of ulcerated skin tumours (OASIS study). Clinical and Experimental Dermatology 47 (5) , pp. 882-888. 10.1111/ced.15037
Item availability restricted.

[thumbnail of ced.15037 (1).pdf] PDF - Accepted Post-Print Version
Restricted to Repository staff only until 2 December 2022 due to copyright restrictions.

Download (7MB)

Abstract

Background Ulceration is a recognised risk factor for SSI, however the proportion of patients developing SSI after excision of an ulcerated skin cancer is unknown. Objectives To determine the proportion of participants with SSI after surgical excision of an ulcerated skin cancer. Secondary aims included feasibility outcomes to inform the design of a randomised controlled trial to investigate the benefits and harms of peri-operative antibiotics following excision of in ulcerated tumours. Methods We undertook a multi-centre prospective, observational study of patients undergoing excision of an ulcerated skin cancer between March 2019-March 2020. Prior to surgical excision, surface swabs of the ulcerated tumours of participants recruited from one centre were undertaken to determine organism growth. Four weeks after surgery, all participants were e-mailed or posted the Wound Healing Questionnaire (WHQ) to determine whether they had developed SSI. Results 148 participants were recruited (105 (70.9%) males; mean (standard deviation) age 77.1 years (12.3). Primary outcome data were available for 116 (78.4%) participants of whom 35 (30.2%) were identified to have SSI using the WHQ with a cut-off score of 8 and 47 (40.5%) with a cut-off score of 6. Using the modified WHQ in participants with wounds left to heal by secondary intention, 33 (28.4%) and 43 (37.1%) were identified to have SSI respectively. Conclusions This prospective evaluation of SSI identified with the WHQ following excision of ulcerated skin cancers demonstrated a high proportion with SSI. The WHQ was acceptable to patients, however further evaluation is required to ensure validity in assessing skin wounds.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Centre for Trials Research (CNTRR)
Publisher: Wiley
ISSN: 0307-6938
Funders: UK Dermatology Clinical Trials Network
Date of First Compliant Deposit: 7 December 2021
Date of Acceptance: 2 December 2021
Last Modified: 13 May 2022 22:22
URI: https://orca.cardiff.ac.uk/id/eprint/145977

Citation Data

Cited 1 time in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics