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The hippocampus as the switchboard between perception and memory

Treder, Matthias S., Charest, Ian, Michelmann, Sebastian, Carmen Martín-Buro, María, Roux, Frédéric, Carceller-Benito, Fernando, Ugalde-Canitrot, Arturo, Rollings, David T., Sawlani, Vijay, Chelvarajah, Ramesh, Wimber, Marie, Hanslmayr, Simon and Staresina, Bernhard P. 2021. The hippocampus as the switchboard between perception and memory. Proceedings of the National Academy of Sciences 118 (50) , e2114171118. 10.1073/pnas.2114171118

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Abstract

How do we adaptively switch from perceiving the external world to retrieving goal-relevant internal memories? To tackle this question, we used—in a cued-recall paradigm—direct intracranial recordings from the human hippocampus complemented by high-density scalp electroencephalography (EEG). We found that a hippocampal signal ∼500 ms after a perceptual cue marks the conversion from external (perceptual) to internal (mnemonic) representations. This sets in motion a recall cascade involving posterior parietal and medial prefrontal cortex, revealed via source-localized and time-resolved EEG alpha power. Together, these results unveil the hippocampal–cortical dynamics supporting rapid and flexible memory recall.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Computer Science & Informatics
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: National Academy of Sciences
ISSN: 0027-8424
Date of First Compliant Deposit: 14 December 2021
Date of Acceptance: 22 October 2021
Last Modified: 14 Dec 2021 13:30
URI: https://orca.cardiff.ac.uk/id/eprint/146060

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