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Mechanochemical organocatalysis: do high enantioselectivities contradict what we might expect?

Williams, Matthew T. J., Morrill, Louis C. ORCID: and Browne, Duncan L. ORCID: 2022. Mechanochemical organocatalysis: do high enantioselectivities contradict what we might expect? ChemSusChem 15 (2) , e202102157. 10.1002/cssc.202102157

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Ball mills input energy to samples by pulverising the contents of the jar. Each impact on the sample or wall of the jar results in an instantaneous transmission of energy in the form of a temperature and pressure increase (volume reduction). Conversely, enantioselective organocatalytic reactions proceed through perceived delicate and well-organised transition states. Does there exist a dichotomy in the idea of enantioselective mechanochemical organocatalysis? This Review provides a survey of the literature reporting the combination of organocatalytic reactions with mechanochemical ball milling conditions. Where possible, direct comparisons of stirred in solution, stirred neat and ball milled processes are drawn with a particular focus on control of stereoselectivity.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Cardiff Catalysis Institute (CCI)
Additional Information: This is an open access article under the terms of the Creative Commons Attribution License
Publisher: Wiley
ISSN: 1864-5631
Funders: EPSRC
Date of First Compliant Deposit: 16 December 2021
Date of Acceptance: 12 November 2021
Last Modified: 24 May 2023 17:08

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