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Liraglutide effects on glycemic control and weight in patients with Type 2 Diabetes mellitus: a real-world, observational study and brief narrative review

Yousef, Consuela Cheriece, Thomas, Abin, Matar, Manar Al, Ghandoura, Lama, Aldossary, Ibrahim, Almuhanna, Sarah Musa, Alhussain, Fatimah, Bishr, Fatmh Al, Aljohani, Raneem Mohammad, Balbaid, Aliya Najeeb, Nouh, Mahmoud, Almarashi, Abdulhalim and AlAmoudi, Reem 2021. Liraglutide effects on glycemic control and weight in patients with Type 2 Diabetes mellitus: a real-world, observational study and brief narrative review. Diabetes Research and Clinical Practice 177 , 108871. 10.1016/j.diabres.2021.108871

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Abstract

Background Glycemic control and weight gain are two essential considerations in the pharmacological management of type 2 diabetes mellitus. Pharmacological agents are effective in lowering blood glucose levels but may result in significant weight gain. Liraglutide effectively maintains glycemic control while reducing weight. Methods This is a real-world study and brief narrative review of the effects of liraglutide on glycemic control and weight in adult patients with type 2 diabetes mellitus. The study uses data extracted from the electronic health record of the Ministry of National Guard-Health Affairs. Results In this study of 348 subjects, there was a statistically significant reduction in hemoglobin A1c of 0.9% (P < .0001) and weight of 2.3 kg (P < .0001). The majority (77.3%) were on concomitant insulin. Subjects with a baseline hemoglobin A1c greater than 9% had a significantly greater reduction than those below 9% (−0.7%; P < .0001). Those with a weight more than 100 kg had a significantly greater reduction than those below 100 kg (-0.9 kg; P = .0096). Conclusion In this real-world, observational study, liraglutide was shown to be effective in improving glycemic control and reducing weight in adult patients with type 2 diabetes mellitus.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Centre for Trials Research (CNTRR)
Publisher: Elsevier
ISSN: 0168-8227
Date of First Compliant Deposit: 18 January 2022
Date of Acceptance: 24 May 2021
Last Modified: 18 Jan 2022 17:15
URI: https://orca.cardiff.ac.uk/id/eprint/146614

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