Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Cross-species comparisons of nanoparticle interactions with innate immune systems: a methodological review

Swartzwelter, Benjamin J., Mayall, Craig, Alijagic, Andi, Barbero, Francesco, Ferrari, Eleonora, Hernadi, Szabolcs, Michelini, Sara, Navarro Pacheco, Natividad Isabel, Prinelli, Alessandra, Swart, Elmer and Auguste, Manon 2021. Cross-species comparisons of nanoparticle interactions with innate immune systems: a methodological review. Nanomaterials 11 (6) , 1528. 10.3390/nano11061528

[thumbnail of nanomaterials-11-01528-v2.pdf]
PDF - Published Version
Available under License Creative Commons Attribution.

Download (4MB) | Preview


Many components of the innate immune system are evolutionarily conserved and shared across many living organisms, from plants and invertebrates to humans. Therefore, these shared features can allow the comparative study of potentially dangerous substances, such as engineered nanoparticles (NPs). However, differences of methodology and procedure between diverse species and models make comparison of innate immune responses to NPs between organisms difficult in many cases. To this aim, this review provides an overview of suitable methods and assays that can be used to measure NP immune interactions across species in a multidisciplinary approach. The first part of this review describes the main innate immune defense characteristics of the selected models that can be associated to NPs exposure. In the second part, the different modes of exposure to NPs across models (considering isolated cells or whole organisms) and the main endpoints measured are discussed. In this synergistic perspective, we provide an overview of the current state of important cross-disciplinary immunological models to study NP-immune interactions and identify future research needs. As such, this paper could be used as a methodological reference point for future nano-immunosafety studies.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Additional Information: This is an open access article distributed under the Creative Commons Attribution License
Publisher: MDPI
ISSN: 2079-4991
Date of First Compliant Deposit: 14 January 2022
Date of Acceptance: 7 June 2021
Last Modified: 24 May 2023 00:07

Citation Data

Cited 8 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item


Downloads per month over past year

View more statistics