Parsing neural circuits of fear learning and extinction across basic and clinical neuroscience: Towards better translation

Namkung, Ho, Thomas, Kerrie L. ORCID: https://orcid.org/0000-0003-3355-9583, Hall, Jeremy ORCID: https://orcid.org/0000-0003-2737-9009 and Sawa, Akira 2022. Parsing neural circuits of fear learning and extinction across basic and clinical neuroscience: Towards better translation. Neuroscience and Biobehavioral Reviews 134 , 104502. 10.1016/j.neubiorev.2021.12.025

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Abstract

Over the past decades, studies of fear learning and extinction have advanced our understanding of the neurobiology of threat and safety learning. Animal studies can provide mechanistic/causal insights into human brain regions and their functional connectivity involved in fear learning and extinction. Findings in humans, conversely, may further enrich our understanding of neural circuits in animals by providing macroscopic insights at the level of brain-wide networks. Nevertheless, there is still much room for improvement in translation between basic and clinical research on fear learning and extinction. Through the lens of neural circuits, in this article, we aim to review the current knowledge of fear learning and extinction in both animals and humans, and to propose strategies to fill in the current knowledge gap for the purpose of enhancing clinical benefits.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Neuroscience and Mental Health Research Institute (NMHRI) Biosciences MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Publisher:	Elsevier
ISSN:	0149-7634
Date of First Compliant Deposit:	25 February 2022
Date of Acceptance:	14 December 2021
Last Modified:	06 Nov 2023 13:43
URI:	https://orca.cardiff.ac.uk/id/eprint/147816

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