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The role of HMGB1 in traumatic brain injury—bridging the gap between the laboratory and clinical studies

Manivannan, S., Wales, E. and Zaben, M. 2021. The role of HMGB1 in traumatic brain injury—bridging the gap between the laboratory and clinical studies. Current Neurology and Neuroscience Reports 21 (12) , 75. 10.1007/s11910-021-01158-3
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Purpose of Review Traumatic brain injury (TBI) is amongst the leading causes of mortality and morbidity worldwide. However, several pharmacological strategies in the clinical setting remain unsuccessful. Mounting evidence implicates High Mobility Group Box protein 1 (HMGB1) as a unique alternative target following brain injury. Herein, we discuss current understanding of HMGB1 in TBI and obstacles to clinical translation. Recent Findings HMGB1 plays a pivotal role as a ‘master-switch’ of neuro-inflammation following injury and in the regulation of neurogenesis during normal development. Animal models point towards the involvement of HMGB1 signalling in prolonged activation of glial cells and widespread neuronal death. Early experimental studies demonstrate positive effects of HMGB1 antagonism on both immunohistochemical and neuro-behavioural parameters following injury. Raised serum/CSF HMGB1 in humans is associated with poor outcomes post-TBI. Summary HMGB1 is a promising therapeutic target post-TBI. However, further studies elucidating receptor, cell, isoform, and temporal effects are required prior to clinical translation.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Publisher: Springer
ISSN: 1528-4042
Date of First Compliant Deposit: 28 February 2022
Date of Acceptance: 18 October 2021
Last Modified: 08 Mar 2022 10:04

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