Abundance of cell bodies can explain the stick model’s failure in grey matter at high bvalue

Palombo, M. ORCID: https://orcid.org/0000-0003-4892-7967, Shemesh, N., Ianus, A., Alexander, D. and Zhang, H. 2018. Abundance of cell bodies can explain the stick model’s failure in grey matter at high bvalue. Presented at: Joint Annual Meeting ISMRM-ESMRMB 2018, 16-21 June 2018.

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Abstract

This work investigates the validity of the stick model used in diffusion-weighted MRI for modelling cellular projections in brain tissue. We hypothesize that the model will fail to describe the signals from grey matter due to an abundance of cell bodies. Using high b-value (≥3 ms/µm ) data from rat and human brain, we show that the assumption fails for grey matter. Using diffusion simulation in realistic digital models of neurons/glia, we demonstrate the breakdown of the assumption can be explained by the presence of cell bodies. Our findings suggest that high b-value data may be used to probe cell bodies.

Item Type:	Conference or Workshop Item (Paper)
Date Type:	Completion
Status:	Published
Schools:	Psychology
Date of First Compliant Deposit:	12 April 2022
Last Modified:	10 Nov 2022 10:42
URI:	https://orca.cardiff.ac.uk/id/eprint/147883

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