Combined diffusion-relaxometry MRI to identify dysfunction in the human placenta

Slator, Paddy ORCID: https://orcid.org/0000-0001-6967-989X, Hutter, J., Palombo, M. ORCID: https://orcid.org/0000-0003-4892-7967, Jackson, L. H., Ho, A., Panagiotaki, E., Chappell, L. C., Rutherford, M. A., Hajnal, J. V. and Alexander, D. 2019. Combined diffusion-relaxometry MRI to identify dysfunction in the human placenta. Magnetic Resonance in Medicine 82 (1) , pp. 95-106. 10.1002/mrm.27733

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Abstract

Purpose: A combined diffusion‐relaxometry MR acquisition and analysis pipeline for in vivo human placenta, which allows for exploration of coupling between T∗2 and apparent diffusion coefficient (ADC) measurements in a sub 10‐minute scan time. Methods: We present a novel acquisition combining a diffusion prepared spin echo with subsequent gradient echoes. The placentas of 17 pregnant women were scanned in vivo, including both healthy controls and participants with various pregnancy complications. We estimate the joint T∗2‐ADC spectra using an inverse Laplace transform. Results: T∗2‐ADC spectra demonstrate clear quantitative separation between normal and dysfunctional placentas. Conclusions: Combined T∗2‐diffusivity MRI is promising for assessing fetal and maternal health during pregnancy. The T∗2‐ADC spectrum potentially provides additional information on tissue microstructure, compared to measuring these two contrasts separately. The presented method is immediately applicable to the study of other organs.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology
Additional Information:	This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Publisher:	Wiley
ISSN:	0740-3194
Date of First Compliant Deposit:	15 March 2022
Date of Acceptance:	27 January 2019
Last Modified:	14 Nov 2023 17:06
URI:	https://orca.cardiff.ac.uk/id/eprint/147927

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