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Traceable 89Zr imaging in positron emission tomography

Fenwick, Andrew 2022. Traceable 89Zr imaging in positron emission tomography. PhD Thesis, Cardiff University.
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Positron emission tomography (PET) is a powerful diagnostic tool in the field of nuclear medicine. The use of novel radioisotopes has significantly increased in recent years and there has been an international drive for new standards of radioactivity for radioisotopes such as 89Zr. To accurately quantify radioactivity distributions in PET images it is necessary to calibrate imaging equipment and perform verification measurements. This thesis presents results from the primary activity standardisation of 89Zr, measurement of a new half-life and gamma emission probabilities, and evaluation of the quantitative accuracy of PET imaging systems used for activity measurement of 89Zr. The measured half-life and gamma emission intensities were evaluated alongside existing work creating a new dataset with lower uncertainties. A methodology was developed for creating traceable imaging objects to be used for calibration and verification measurements in PET imaging. Uncertainties were estimated for each stage of the measurement chain and combined where appropriate to give overall uncertainty budgets. The results showed that traceable imaging measurements are achievable in both preclinical and clinical PET systems, but uncertainty assessment is challenging when dealing with proprietary acquisition and reconstruction algorithms. Several future projects are presented, and it is hoped these projects will further develop the metrology required for traceable PET imaging in the clinical environment and open the door to a new era of accuracy and precision in PET activity quantification.

Item Type: Thesis (PhD)
Date Type: Completion
Status: Unpublished
Schools: Medicine
Date of First Compliant Deposit: 14 March 2022
Last Modified: 14 Dec 2022 02:27

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