Exploring the effects of cigarette smoking on inflammatory bowel disease using Mendelian randomisation

Jones, Daniel P., Richardson, Tom G., Davey Smith, George, Gunnell, David, Munafo, Marcus R. and Wootton, Robyn E. 2020. Exploring the effects of cigarette smoking on inflammatory bowel disease using Mendelian randomisation. Crohn's and Colitis 360 2 (1) , otaa018. 10.1093/crocol/otaa018

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Abstract

Background. Previous observational evidence has suggested an association between smoking and inflammatory bowel disease (IBD). <br><br>Methods. We used observational techniques followed by Mendelian randomisation (MR) to explore if smoking is a causal factor in the development of IBD and its subtypes.<br><br>Results. In those who have ever smoked, we observed increased risk of IBD, and, in current smokers, we observed increased risk of Crohn’s disease and decreased risk of Ulcerative Colitis. However, our MR analyses found little evidence that smoking affects the development of IBD. <br><br>Conclusion. Overall, our results suggest that smoking does not causally influence the risk of IBD.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Additional Information:	This is an open access article distributed under the terms of the Creative Commons CC BY license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
ISSN:	2631-827X
Date of First Compliant Deposit:	18 March 2022
Last Modified:	14 May 2023 20:44
URI:	https://orca.cardiff.ac.uk/id/eprint/148457

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