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Plasma lipid alterations in young adults with psychotic experiences: A study from the Avon Longitudinal Study of Parents and Children cohort

Yin, Xiaofei, Mongan, David, Cannon, Mary, Zammit, Stanley ORCID: https://orcid.org/0000-0002-2647-9211, Hyötyläinen, Tuulia, Oresic, Matej, Brennan, Lorraine and Cotter, David R. 2022. Plasma lipid alterations in young adults with psychotic experiences: A study from the Avon Longitudinal Study of Parents and Children cohort. Schizophrenia Research 243 , pp. 78-85. 10.1016/j.schres.2022.02.029

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Abstract

Background Psychotic experiences (PEs) are associated with an increased risk of future psychotic and non-psychotic mental disorders. The identification of biomarkers of PEs may provide insights regarding the underlying pathophysiology. Methods The current study applied targeted lipidomic approaches to compare plasma lipid profiles in participants from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort who did (n = 206) or did not (n = 206) have PEs when aged approximately 24 years. Results In total, 202 lipids including 8 lipid classes were measured by using ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS). Eight lipid clusters were generated. Thirteen individual lipids were nominally significantly higher in the PEs group compared to the control group. After correction for multiple comparisons, 9 lipids comprising 3 lysophosphatidylcholines (LPCs), 2 phosphatidylcholines (PCs) and 4 triacylglycerols (TGs) remained significant. In addition, PEs cases had increased levels of TGs and LPCs with a low double bond count. Conclusions These findings indicate plasma lipidomic abnormalities in individuals experiencing PEs. The lipidomic profile measures could aid our understanding of the underlying pathophysiological mechanisms.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Additional Information: This is an open access article under the CC BY license
Publisher: Elsevier
ISSN: 0920-9964
Date of First Compliant Deposit: 29 March 2022
Date of Acceptance: 18 February 2022
Last Modified: 06 May 2023 03:26
URI: https://orca.cardiff.ac.uk/id/eprint/148957

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