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Identifying factors associated with 3MDR treatment outcome; A Phase II randomised controlled trial of virtual reality and exposure therapy for military veterans with PTSD

Barawi, Kali 2021. Identifying factors associated with 3MDR treatment outcome; A Phase II randomised controlled trial of virtual reality and exposure therapy for military veterans with PTSD. PhD Thesis, Cardiff University.
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Abstract

Trauma-focused (TF) psychological therapy has been shown to be the most effective treatment for Post Traumatic Stress Disorder (PTSD). However, a growing number of military veterans have been shown to either not respond or engage with existing treatment, which has resulted in a diagnosis of Treatment-Resistant (TR) PTSD. There is an urgent need to develop more effective and personalised treatments for military veterans with TR-PTSD. As with existing treatment, not all individuals will respond or engage with novel treatments, therefore identifying factors associated with treatment outcome is essential for improving its effectiveness. The aim of this thesis is to explore factors associated with treatment outcome. A systematic review of factors associated with psychological treatment outcome for PTSD was conducted to identify the most commonly reported factors. The factors identified in the systematic review were applied to explore factors associated with outcome in a Randomised Controlled Trial (RCT) of Multi-Modular Motion assisted Memory Desensitization and Reconsolidation (3MDR). 3MDR is a novel intervention that combines virtual reality, movement, personalised music and photographs to expose the participant to their trauma. The RCT included 40 military veterans with TR-PTSD to identify whether 3MDR was more effective than waiting list control. A quantitative analysis involved multiple regression analysis to examine whether any of the factors identified in the systematic review were associated with the 3MDR treatment outcome, as measured by a reduction in Clinician-Administered Post Traumatic Stress Disorder Scale for Diagnostic and Statistical Manual of Mental Disorders 5th edition scores. Qualitative thematic analysis was conducted on semi-structured interviews with 11 military veterans from the 3MDR sample to explore any novel factors associated with treatment outcome. No clear picture with respect to factors associated with outcome emerged and the results indicate that further research is required to examine factors associated with treatment outcome in a larger sample of routinely collected data before any clinical recommendation can be made.

Item Type: Thesis (PhD)
Date Type: Completion
Status: Unpublished
Schools: Medicine
Date of First Compliant Deposit: 22 April 2022
Last Modified: 22 Apr 2022 15:43
URI: https://orca.cardiff.ac.uk/id/eprint/149294

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