Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Adhesion of living cells: mechanisms of adhesion and contact models

Borodich, Feodor M. ORCID:, Galanov, Boris A., Keer, Leon M. and Suarez-Alvarez, Maria M. 2022. Adhesion of living cells: mechanisms of adhesion and contact models. Borodich, Feodor M. and Jin, Xiaoqing, eds. Contact Problems for Soft, Biological and Bioinspired Materials. Biologically-Inspired Systems, Vol. 15. Springer, pp. 1-30. (10.1007/978-3-030-85175-0_1)

Full text not available from this repository.


All known biological organisms consist of cells. Contact probing of cells is one of the preferred methods of studying cells’ mechanical properties. Here we discuss various questions related to nanotechnology and contact probing of cells. The main goals of the review are twofold: (1) to explain some specific features of nanoscale mechanics and modern experimental techniques used in modern nanotechnology to experts in theoretical aspects of classical solid mechanics; and (2) to describe the main assumptions and approaches employed in mechanics of adhesive contacts, in particular in applications to contact probing of living cells, to experts in experimental biology. First, historical overview of the methods for studying cells are given, these include methods of microscopy and contact mechanics. Then the mechanisms of adhesion between cells are described. It is shown that adhesive interactions between cells may be caused by various physical and chemical mechanisms. Although all these mechanisms have the same electromagnetic nature, their manifestations may be rather different. Theories of adhesive contact between elastic spheres are discussed. It is argued that the classic theories such as Johnson-Kendall-Roberts and Derjaguin-Muller-Toporov should be modified in order to reflect the initial stresses in cell membranes. After these models may be applied to cells assuming that the cell surfaces may be locally approximated by spherical surfaces. Finally, we discuss the depth-sensing indentation methods that may be used for extraction of adhesive and mechanical properties of cell membranes.

Item Type: Book Section
Date Type: Publication
Status: Published
Schools: Engineering
Publisher: Springer
ISBN: 9783030851743
ISSN: 2211-0593
Last Modified: 10 Nov 2022 11:08

Actions (repository staff only)

Edit Item Edit Item