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Efficacy of non-surgical monotherapies for hidradenitis suppurativa: a systematic review and network meta-analyses of randomized trials

Gupta, Aditya K., Shear, Neil H., Piguet, Vincent and Bamimore, Mary A. 2022. Efficacy of non-surgical monotherapies for hidradenitis suppurativa: a systematic review and network meta-analyses of randomized trials. Journal of Dermatological Treatment 33 (4) , pp. 2149-2160. 10.1080/09546634.2021.1927949

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Abstract

Objective We determined the relative efficacy of non-surgical monotherapies for hidradenitis suppurativa (HS). Methods Network meta-analyses were conducted to determine treatments’ surface under the cumulative ranking curve (SUCRA) value (i.e. an estimate that ranks efficacy); pairwise comparisons were conducted. Results and conclusions Ten trials were eligible for quantitative analyses; however, all did not have a common endpoint. Outcomes corresponded to pain severity, clinical response, quality of life and abscess count. For pain reduction, infliximab was ranked most efficacious (SUCRA = 94%) compared to bermekimab, anakinra and placebo; infliximab reduced pain more significantly (p < .05) than anakinra and then placebo. For the occurrence of clinical response, bimekizumab had the highest SUCRA (67%) relative to adalimumab, anakinra and placebo; bimekizumab was more efficacious than placebo (p < .05). For the quality of life in mild HS, Botox had the highest SUCRA (94%) compared to adalimumab and placebo; Botox was more efficacious than placebo (p < .05). For reduction in abscess count, oral tetracycline had the highest SUCRA (48%) compared to topical clindamycin and vehicle. Our work—being the first NMA study on non-surgical HS monotherapies—contributes to the comparative effectiveness literature for this condition.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Taylor and Francis
ISSN: 0954-6634
Date of Acceptance: 5 May 2021
Last Modified: 26 Oct 2022 12:51
URI: https://orca.cardiff.ac.uk/id/eprint/149829

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