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Enigmatic inflammasomes - sequel (Part 2)

Triantafilou, Kathy ORCID: 2021. Enigmatic inflammasomes - sequel (Part 2). Immunology 163 (4) , pp. 345-347. 10.1111/imm.13387

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In this issue, we introduce the second part of our review series focusing on lesser-known enigmatic inflammasomes. This part of the collection introduces one more under-studied NLR, NLRP7, and not only its role as a regulator of inflammation in response to bacterial infections but also its non-inflammasome role in early pregnancy. In addition, the enigmatic function of extracellular ASC specks is also introduced, where extracellular ASC specks are presented as ‘danger signals’ to propagate inflammation. The series is concluded with an article that reviews the immunometabolic regulation of all of these lesser-known NLRs, demonstrating that metabolic regulation of inflammasome activation is central for the whole NLR family. These three reviews, together with the four articles that were published in the first part of the series in December 2020, offer new insights into the complex functions of NLRs, well beyond the well-known NLRP3. The review series as a whole provides a thought-provoking platform with some of the latest findings in the NLR field and sparks our imagination into what might be discovered in this space in the future.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Wiley
ISSN: 0019-2805
Date of First Compliant Deposit: 9 January 2023
Last Modified: 15 May 2023 20:07

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