Efficacy of early biopsy in kidney allograft recipients with delayed graft function.

Puliatti, C., Rizzello, A., Ilham, M. and Asderakis, A. ORCID: https://orcid.org/0000-0001-6859-2020 2007. Efficacy of early biopsy in kidney allograft recipients with delayed graft function. Transplantation Proceedings 39 (6) , pp. 1803-1804. 10.1016/j.transproceed.2007.05.015

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Abstract

t is accepted that kidney transplants that display delayed graft function (DGF) show poorer survival and function, particularly when an acute rejection episode (ARE) occurs. A diagnostic biopsy to establish the reason for DGF, or acknowledge an ARE, even if borderline, can improve short- and long-term graft survivals. From January 2002 to September 2006 we retrospectively evaluated 358 kidney transplant recipients. We performed a biopsy to evaluate the cause of DGF in all patients who required dialysis, or had serum creatinine levels that increased, remained unchanged, or decreased less than 10% per day on three consecutive days during the first week after transplantation. An ARE was found in 18.8% (n = 19) of the biopsies. Early biopsy for patients with DGF is a safe method that allows uncovering of an ARE that would otherwise be undetected. The immediate recognition and treatment of rejection episodes can certainly increase long-term survival and function of renal transplants.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Elsevier
ISSN:	0041-1345
Last Modified:	10 Nov 2022 11:28
URI:	https://orca.cardiff.ac.uk/id/eprint/150662

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