Cytomegalovirus infection management in solid organ transplant recipients across European centers in the time of molecular diagnostics: An ESGICH survey

Navarro, David, San-Juan, Rafael, Manuel, Oriol, Gimenez, Estela, Fernandez-Ruiz, Mario, Hirsch, Hand H., Grossi, Paulo Antonio, Aguado, Jose MAria, ESGICH CMV Survey Study Group and Asderakis, Argiris ORCID: https://orcid.org/0000-0001-6859-2020 2017. Cytomegalovirus infection management in solid organ transplant recipients across European centers in the time of molecular diagnostics: An ESGICH survey. Transplant Infectious Disease 19 (6) , e12773. 10.1111/tid.12773

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Abstract

Background Scant information is available about how transplant centers are managing their use of quantitative molecular testing (QNAT) assays for active cytomegalovirus (CMV) infection monitoring in solid organ transplant (SOT) recipients. The current study was aimed at gathering information on current practices in the management of CMV infection across European centers in the era of molecular testing assays. Methods A questionnaire-based cross-sectional survey study was conducted by the European Study Group of Infections in Immunocompromised Hosts (ESGICH) of the Society of Clinical Microbiology and Infectious Diseases (ESCMID). The invitation and a weekly reminder with a personal link to an Internet service provider (https://es.surveymonkey.com/) was sent to transplant physicians, transplant infectious diseases specialists, and clinical virologists working at 340 European transplant centers. Results Of the 1181 specialists surveyed, a total of 173 responded (14.8%): 73 transplant physicians, 57 transplant infectious diseases specialists, and 43 virologists from 173 institutions located at 23 different countries. The majority of centers used QNAT assays for active CMV infection monitoring. Most centers preferred commercially available real-time polymerase chain reaction (RT-PCR) assays over laboratory-developed procedures for quantifying CMV DNA load in whole blood or plasma. Use of a wide variety of DNA extraction platforms and RT-PCR assays was reported. All programs used antiviral prophylaxis, preemptive therapy, or both, according to current guidelines. However, the centers used different criteria for starting preemptive antiviral treatment, for monitoring systemic CMV DNA load, and for requesting genotypic assays to detect emerging CMV-resistant variants. Conclusions Significant variation in CMV infection management in SOT recipients still remains across European centers in the era of molecular testing. International multicenter studies are required to achieve commutability of CMV testing and antiviral management procedures.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Additional Information:	AUTHORS OF ESGICH CMV SURVEY Maja Abram, Rijeka Clinical Hospital Center, Rijeka (Croatia); Daniel Abramowicz, Antwerpen Univ Hosp, Antwerpen (Belgium); José-María Álamo, Virgen del Rocio Hospital Infantil, Sevilla (Spain); Sehnaz Alp, Hacettepe University Hospitals, Ankara (Turkey); Amado Andres-Belmonte, Doce de Octubre Hosp Univ, Madrid (Spain); Pouleur Anne-Catherine, Cliniques universitaires St Luc, Brussels (Belgium); Barbara Antonelli, Milano Policlinico Univ Hosp, Milano (Italy); Miha Arnol, Ljubljana University Medical Centre, Ljubljana (Slovenia); Ayse Hande Arslan, Baskent Univ Hosp, Ankara (Turkey); Argiris Asderakis, Cardiff Transplant Unit, University Hospital of Wales, Cardiff (United Kindom); Fausto Baldanti, San Matteo Hosp/Univ of Pavia, Pavia (Italy); Isabel Beneyto-Castello, La Fe Hospital Adultos, Valencia (Spain); Kabamba Mukadi Benoit, St Luc Clin Univ, Brussels (Belgium); Marino Blanes, La Fe Hospital Adultos, Valencia (Spain); Katia Boggian, Kantonsspital St Gallen, St Gallen (Switzerland); Renzo Bonofiglio, Annunziata Viamigliori, Cosenza (Italy); Marina Bubonja-Sonje, Rijeka Clinical Hospital Center, Rijeka (Croatia); Sophie Caillard, Strasbourg UH, Strasbourg (France); Jorge Calvo, Doce de Octubre Hosp Univ, Madrid (Spain); Alessandro Capone, National Institue Infectious Diseases “L. Spallanzani” IRCCS, Rome (Italy); Gianni Cappelli, Azienda Ospedaliero—Universitaria di Modena, Modena (Italy); Mario Carmellini, Azienda Ospedaliero Universitaria Senese, Siena (Italy); Fernando Casafont, Valdecilla Univ Hosp, Santander (Spain); M. Beatriz Castro-Hernandez, Universitario de Canarias, Tenerife (Spain); Pilar Catalan, Gregorio Marañón G. Hosp, Madrid (Spain); Bressollette-Bodin Celine, Nantes University Hospital, Nantes (France); Berger Christoph, University Children's Hospital Zurich, Zurich (Switzerland); Elisa Cordero, Hospital Universitario Virgen del Rocío, Sevilla (Spain); Cristina Costa, University Hospital Città della Salute e della Scienza di Torino, Torino (Italy); Julien Coussement, CUB-Hospital Erasme, Université Libre de Bruxelles, Brussels (Belgium); Valentin Cuervas-Mons, Puerta de Hierro G. Hosp, Madrid (Spain); Miruna David, Queen Elizabeth Hosp, Birmingham (United Kindom); Julián de la Torre Cisneros, Reina Sofia Univ Hosp, Cordoba (Spain); Juan F. Delgado, Doce de Octubre Hosp Univ, Madrid (Spain); Luca Dello Strologo, Bambino Gesu, Ospedale Ped, Rome (Italy); Olivier Detry, Liege Ctr Hosp Univ Sart-Tilman, Liege (Belgium); Laura Dexter, Gardiff Hospital, Cardiff (United Kindom); Hoffmann Dieter, Tartu University Hospital, Munich (Germany); Anna Meis-Hübinger, Institute of Virology, University of Bonn Medical Centre, Bonn (Germany); Eric Epailly, Strasbourg UH, Strasbourg (France); Bo-Goran Ericzon, Karolinska Univ Hosp, Stockholm (Sweden); Britt-Marie Eriksson, Uppsala Univ Hosp, Uppsala (Sweden); Imre Fehervari, Semmelweis Med Univ, Budapest (Hungary); Susan FitzGerald, St Vincent's Hospital, Dublin (Ireland); Lola Folgueira, Doce de Octubre Hosp Univ, Madrid (Spain); Jesus Fortun, Ramón y Cajal GH, Madrid (Spain); Erica Franceschini, Università di Modena e Reggio Emilia, Modena (Italy); Proot Francois, Claude Huriez CHR Lille, Lille (France); Vanda Friman, Sahlgrenska Univ Hosp, Gothenburg (Sweden); Silvius Frimmel, Rostock Univ Med Faculty, Rostock (Germany); Christian Garzoni, Clinica Luganese, Lugano (Switzerland); Adelina Gimeno, Alicante Hospital, Alicante (Spain); Effrossyni Gkrania-Klotsas, Addenbrooke's NHS Trust, Cambridge (United Kindom); Mark Greer, Hochschule Hannover Med, Hannover (Germany); Paul Griffiths, University College London, London (United Kindom); Josep M. Grinyó, Bellvitge Hospital, Barcelona (Spain); Giovanni Guaraldi, Università di Modena e Reggio Emilia, Modena (Italy); Girish Gupte, Birmingham Children's Hospital, Birmingham (United Kindom); Abdul Hammad, Royal Liverpool & Broadgreen Univ, Hosp, Liverpool (United Kindom); Ian Hart, Royal Liverpool & Broadgreen Univ, Hosp, Liverpool (United Kindom); Ilkka Helanterä, Helsinki Univ Ctr Hosp, Helsinki (Finland); Rachel Hellemans, Antwerpen Univ Hosp, Antwerpen (Belgium); Domingo Hernández, Hospital Carlos Haya, Malaga (Spain); Jose Ignacio Herrero, Clin Univ de Navarra, Pamplona (Spain); Christian Hiesse, Hopital Foch Suresnes, Suresnes (France); Hans H. Hirsch, Kantonsspital Basel, Basel (Switzerland); Maria Hoppe-Lotichius, Mainz Transp Ctr, Johannes-Gutenberg Univ, Mainz (Germany); Ewa Hryniewiecka, Medical University of Warsaw, Warsaw (Poland); Peter Jaksch, Medical University Vienna, Vienna (Austria); Lerut Jan, St Luc Clin Univ, Brussels (Belgium); Brion Jean Paul, Grenoble Michallon CHU, Grenoble (France); Soren Jensen-Fangel, Skejby Hosp, Univ Aarhus, Aarhus (Denmark); Steinmann Joerg, Essen Univ Clin, Essen (Germany); Vanhaecke Johan, Gasthuisberg Univ Hosp, Leuven (Belgium); Ingolfur Johannessen, Royal Infirmary of Edinburgh (NHS Lothian), Edinburgh (United Kindom); Inger Johansson, Sahlgrenska Univ Hosp, Gothenburg (Sweden); Nassim Kamar, Toulouse CHU (Ranguel Larrey), Toulouse (France); Filiz Kizilates, Antalya Training and Research Hospital Transplant Center, Antalya (Turkey); Christiane Knoop, Erasme-Clin Univ de Bruxelles,, Brussels (Belgium); Belec Laurent, Hôpital Européen Georges Pompidou, Paris (France); Augusto Lauro, Sant’ Orsola-Malpighi Univ Hosp, Bologna (Italy); Irmeli Lautenschlager, Helsinki Univ Ctr Hosp,, Helsinki (Finland); Ricardo Lauzurica, Germans Trias i Pujol, Barcelona (Spain); Professor Dr. U. G. Liebert, Leipzig University, Institute of Virology, University Hospital, Leipzig (Germany); PaolaLilla dela Monica, Azienda Ospedaliera San Camillo-Forlanini Roma, Rome (Italy); Laura Llado, Bellvitge Hospital, Barcelona (Spain); Rafael Lopez-Andujar, La Fe Hospital Adultos, Valencia (Spain); Filippo Luciani, Azienda Ospedaliera di Cosenza, Cosenza (Italy); Massimo Maccherini, Ospedali Riuniti (Pol. Le Scotte) Siena, Siena (Italy); Johan Maertens, Gasthuisberg Univ Hosp, Leuven (Belgium); Umberto Maggiore, Azienda Ospedaliero—Universitaria di Parma (Ospedale Maggi), Parma (Italy); Alejandro Manrique, Doce de Octubre Hosp Univ, Madrid (Spain); Maria Angeles Marcos, Clinico Barcelona Univ Hosp, Barcelona (Spain); Ivana Marekovic, University Hospital Centre Zagreb, Zagreb (Croatia); Nuno Marques, Univ de Coimbra Hosp, Coimbra (Portugal); Nitschke Martin, Lübeck, University Hostpital, Transplant Center, Luebeck (Germany); Neau Martine, Pellegrin CHU Bordeaux, Bordeaux (France); Ana Martinez-Sapiña, Hospital Universitario Miguel Servet, Zaragoza (Spain); M. Luisa Mateos Lindemann, Ramón y Cajal GH, Madrid (Spain); Auxiliadora Mazuecos, Puerta Del Mar UH, Cadiz (Spain); Esperanza Merino, Alicante Hospital, Alicante (Spain); Francesc Moreso, Vall D'Hebron Gen Hosp, Barcelona (Spain); Nicolas Mueller, Zurich Univ Hosp, Zurich (Switzerland); David Muir, Imperial College Healthcare NHS Trust, London (United Kingdom); Alessandra Mularoni, ISMETT, Palermo, Palermo (Italy); Patricia Muñoz, Gregorio Marañón G. Hosp, Madrid (Spain); Agustín Muñoz-Sanz, Infanta Cristina Hospital, Badajoz (Spain); Silvio Nadalin, Tuebingen Univ, Tuebingen (Germany); Laura Ambra Nicolini, IRCCS San Martino IST, Genova (Italy); Mario Nosotti, Ospedale Maggiore Policlinico Milano, Milano (Italy); Joanne O. Gorman, National Virus Reference Laboratory Dublin Ireland, Dublin (Ireland); Husam Osman, Queen Elizabeth Hosp, Birmingham (United Kindom); Elizaveta Padalko, Ghent Univ Hosp, Ghent (Belgium); Begoña Palop-Borrás, Regional Carlos Haya, Malaga (Spain); Javirparmer, Papworth Hospital, Cambridge (United Kindom); Sonia Pascual, Alicante Hospital, Alicante (Spain); María José Pena López, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria (Spain); José Luis Pérez-Sáenz, Hospital Universitario Son Espases, Palma de Mallorca (Spain); Mauro Pistello, Azienda Ospedaliero-Universitaria Pisana, Pisa (Italy); M. Francisca Portero, Puerta de Hierro G. Hosp, Madrid (Spain); Elisabeth Puchhammer, Medical University Vienna, Vienna (Austria); Sara Racca, Ospedale San Raffaele, Milano (Italy); Janette Rahamat-Langendoen, St Radboud Hosp, Nymegen (The Netherlands); Antonio Ramos, Puerta de Hierro G. Hosp, Madrid (Spain); Esther Ramos Boluda, La Paz Hospital Infantil, Madrid (Spain); Mohammad Raza, Northern Gen Hosp, Sheffield (United Kingdom); Enrico Regalia, Instituto Tumori Milano Fondazione IRCCS, Milano (Italy); Gabriel Reina, Clin Univ de Navarra, Pamplona (Spain); Tomas Reischig, Charles University Teaching Hospital, Pilsen (Czech Republic); Stefan Reuter, Muenster Univ Hosp, Muenster (Germany); M. Luisa Rodríguez-Ferrero, Gregorio Marañón G. Hosp, Madrid (Spain); Emmanuel Roilides, Aristotle University, Hippokration Hospital, Thessaloniki (Others); Serena Rolla, Ospedale San Raffaele, Milano (Italy); Halvor Rollag, Rikshosp-The Nat'l Hosp Oslo, Oslo (Norway); Lionel Rostaing, Grenoble Michallon CHU, Grenoble (France); Francesco Paolo Russo, University Hospital Padova, Padova (Italy); Núria Sabé, Bellvitge Hospital, Barcelona (Spain); Faouzi Saliba, Paul Brousse Hosp, Paris (France); Ana Sánchez-Fructuoso, Clinico San Carlos, Madrid (Spain); Giorgio Scotton, Treviso Gen Hosp, Ospedale Cà Foncello, Treviso (Italy); Nuria Serra, Fundacio Puigvert, Barcelona (Spain); Dino Sgarabotto, Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone, Padova (Italy); Jelena Stojanovic, Evelina London Children's Hospital (Guy's Hospital), London (United Kindom); Meltem Tasbakan, Ege Univ Med Sch, Izmir (Turkey); Mauricio Telenti, Hospital Universitario Central de Asturias, Oviedo (Spain); Gabriella Terhes, Institute of Clinical Microbiology, University of Szeged, Szeged (Hungary); Stefan Thorban, Munchen-Klin Rechts Isar Tech Univ, Munich (Germany); Nijaz Tihic, Tuzla University Clinical Center, Tuzla (Bosnia and Herzegovina); Giovanna Travi, Niguarda Osp, Milano (Italy); Patrizia Tulissi, Santa Maria della Misericordia, Udine, Udine (Italy); Christian Van Delden, Geneva Univ Hosp, Geneva (Switzerland); Coretta Van Leer, Groningen University Medical Center, Groningen (The Netherlands); Inge Van Loo, Maastricht Univ Hosp, Maastricht (The Netherlands); Marina Varga, Semmelweis Med Univ, Budapest (Hungary); María Aránzazu Varona-Bosque, Ntra Sra De Candelaria University Hospital, Santa Cruz de Tenerife (Spain); Massimiliano Veroux, Azienda Ospedaliero-Universitaria Policlinico/Ferraroto Cata, Catania (Italy); Ana Vila-Santandreu, San Joan de Deu Hospital, Barcelona (Spain); Sheila Waugh, Freeman Hospital, Newcastle (United Kindom); Lada Zibar, University Hospital Centre Osijek, Osijek (Croatia); Stefan Zschiedr, Freiburg Univ Hosp, Freiburg (Germany).
Publisher:	Wiley
ISSN:	1398-2273
Date of Acceptance:	11 June 2017
Last Modified:	10 Nov 2022 11:28
URI:	https://orca.cardiff.ac.uk/id/eprint/150669

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