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Borane promoted aryl transfer reaction for the synthesis of α-aryl functionalised β-hydroxy and β-keto esters

Kaehler, Tanja, Lorenz, Jonas, Ould, Darren M. C., Engl, Dorothea, Santi, Micol, Gierlichs, Lukas, Wirth, Thomas ORCID: https://orcid.org/0000-0002-8990-0667 and Melen, Rebecca L. ORCID: https://orcid.org/0000-0003-3142-2831 2022. Borane promoted aryl transfer reaction for the synthesis of α-aryl functionalised β-hydroxy and β-keto esters. Organic and Biomolecular Chemistry 20 (21) , pp. 4298-4302. 10.1039/D2OB00643J

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Abstract

The synthesis of a series of α-aryl or α-alkyl functionalised β-hydroxy and β-keto esters has been achieved by reacting α-diazoesters with boranes, and aldehydes, ketones, anhydrides, nitriles, esters or isocyanates. In a mild reaction protocol, 26 examples are presented in yields up to 73%.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Cardiff Catalysis Institute (CCI)
Additional Information: This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Publisher: Royal Society of Chemistry
ISSN: 1477-0520
Funders: EPSRC
Date of First Compliant Deposit: 27 June 2022
Date of Acceptance: 7 May 2022
Last Modified: 10 Nov 2022 11:31
URI: https://orca.cardiff.ac.uk/id/eprint/150817

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