Genetics of attention-deficit hyperactivity disorder

Langley, Kate ORCID: https://orcid.org/0000-0002-2033-2657, Martin, Joanna ORCID: https://orcid.org/0000-0002-8911-3479 and Thapar, Anita ORCID: https://orcid.org/0000-0002-3689-737X 2022. Genetics of attention-deficit hyperactivity disorder. Current Topics in Behavioral Neurosciences, Berlin, Heidelberg: pp. 1-26. (10.1007/7854_2022_338)

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Abstract

Attention-Deficit Hyperactivity Disorder (ADHD) has long been recognized as being a highly heritable condition and our understanding of the genetic contributions to ADHD has grown over the past few decades. This chapter will discuss the studies that have examined its heritability and the efforts to identify specific genetic risk-variants at the molecular genetic level. We outline the various techniques that have been used to characterize genetic contributions to ADHD, describing what we have learnt so far, what there is still to learn and the methodologies that can be used to further our knowledge. In doing so we will discuss research into rare and common genetic variants, polygenic risk scores, and gene–environment interplay, while also describing what genetic studies have revealed about the biological processes involved in ADHD and what they have taught us about the overlap between ADHD and other psychiatric and somatic disorders. Finally, we will discuss the strengths and limitations of the current methodologies and clinical implications of genetic research to date.

Item Type:	Book Section
Date Type:	Published Online
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
ISSN:	1866-3370
Date of First Compliant Deposit:	29 June 2022
Date of Acceptance:	11 May 2022
Last Modified:	30 Nov 2022 08:11
URI:	https://orca.cardiff.ac.uk/id/eprint/150871

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