Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Continuous flow mechanochemistry: reactive extrusion as an enabling technology in organic synthesis

Bolt, Robert R. A., Leitch, Jamie A., Jones, Andrew C., Nicholson, William I. and Browne, Duncan L. 2022. Continuous flow mechanochemistry: reactive extrusion as an enabling technology in organic synthesis. Chemical Society Reviews 51 (11) , pp. 4243-4260. 10.1039/D1CS00657F

[thumbnail of d1cs00657f.pdf]
PDF - Published Version
Available under License Creative Commons Attribution Non-commercial.

Download (10MB) | Preview


apid and wide-ranging developments have established mechanochemistry as a powerful avenue in sustainable organic synthesis. This is primarily due to unique opportunities which have been offered in solvent-free – or highly solvent-minimised – reaction systems. Nevertheless, despite elegant advances in ball-milling technology, limitations in scale-up still remain. This tutorial review covers the first reports into the translation from “batch-mode” ball-milling to “flow-mode” reactive extrusion, using twin-screw extrusion.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Chemistry
Additional Information: This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence
Publisher: Royal Society of Chemistry
ISSN: 0306-0012
Funders: Leverhulme Trust, European Union, WEFO, Cardiff University and Cambridge Reactor Design for a Knowledge Economy and Skills Scholarship (KESS2)
Date of First Compliant Deposit: 1 July 2022
Date of Acceptance: 4 May 2022
Last Modified: 04 Jul 2022 10:00

Citation Data

Cited 4 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item


Downloads per month over past year

View more statistics