Evaluating the alginate oligosaccharide (OligoG) as a therapy for Burkholderia cepacia complex cystic fibrosis lung infection

Fischer, Rianald, Schwarz, Carsten, Weiser, Rebecca ORCID: https://orcid.org/0000-0003-3983-3272, Mahenthiralingam, Eshwar ORCID: https://orcid.org/0000-0001-9014-3790, Smerud, Knut, Meland, Nils, Flaten, Hugo and Rye, Philip D. 2022. Evaluating the alginate oligosaccharide (OligoG) as a therapy for Burkholderia cepacia complex cystic fibrosis lung infection. Journal of Cystic Fibrosis 21 (5) , pp. 821-829. 10.1016/j.jcf.2022.01.003

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Abstract

OligoG has previously shown potentiation of aztreonam against Burkholderia cepacia complex (Bcc) through biofilm disruption. A randomized, double-blind, placebo-controlled cross-over design was used to evaluate safety and efficacy of inhaled OligoG as a therapy for Bcc-infected CF patients taking aztreonam. Subjects received OligoG (1050 mg daily) or matching placebo for 28-days. Of 14 subjects completing the study, 8 showed a mean decrease in total bacterial CFU's (0.82 log10) after OligoG treatment. There was a reduction in mean Bcc CFU's (2.19 log10) after OligoG treatment but this was not statistically significant. Rheology analysis showed improvements in phase-angle after OligoG, but there was no statistically significant improvement in lung function parameters. Six out of 12 QoL summary scores showed relative improvement after OligoG treatment compared to placebo. There was a favourable safety profile for OligoG. Potential for reducing Bcc warrants further investigation of OligoG for the treatment of infection in CF.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	Elsevier
ISSN:	1569-1993
Date of First Compliant Deposit:	27 July 2022
Date of Acceptance:	9 January 2022
Last Modified:	07 Nov 2023 04:32
URI:	https://orca.cardiff.ac.uk/id/eprint/151498

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