Time to retire the serial Papez circuit: Implications for space, memory, and attention

Aggleton, John P. ORCID: https://orcid.org/0000-0002-5573-1308, Nelson, Andrew J. D. ORCID: https://orcid.org/0000-0002-5171-413X and O'Mara, Shane M. 2022. Time to retire the serial Papez circuit: Implications for space, memory, and attention. Neuroscience and Biobehavioral Reviews 140 , 104813. 10.1016/j.neubiorev.2022.104813

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Abstract

After more than 80 years, Papez serial circuit remains a hugely influential concept, initially for emotion, but in more recent decades, for memory. Here, we show how this circuit is anatomically and mechanistically naïve as well as outdated. We argue that a new conceptualisation is necessitated by recent anatomical and functional findings that emphasize the more equal, working partnerships between the anterior thalamic nuclei and the hippocampal formation, along with their neocortical interactions in supporting, episodic memory. Furthermore, despite the importance of the anterior thalamic for mnemonic processing, there is growing evidence that these nuclei support multiple aspects of cognition, only some of which are directly associated with hippocampal function. By viewing the anterior thalamic nuclei as a multifunctional hub, a clearer picture emerges of extra-hippocampal regions supporting memory. The reformulation presented here underlines the need to retire Papez serially processing circuit.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology
Publisher:	Elsevier
Funders:	Wellcome Trust
Date of First Compliant Deposit:	16 August 2022
Date of Acceptance:	2 August 2022
Last Modified:	06 Nov 2023 17:12
URI:	https://orca.cardiff.ac.uk/id/eprint/151960

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