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Inflammatory bowel disease: A review of pre-clinical murine models of human disease

Katsandegwaza, Brunette, Horsnell, William and Smith, Katherine ORCID: https://orcid.org/0000-0001-8150-5702 2022. Inflammatory bowel disease: A review of pre-clinical murine models of human disease. International Journal of Molecular Sciences 23 (16) , 9344. 10.3390/ijms23169344

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Abstract

Crohn’s disease (CD) and ulcerative colitis (UC) are both highly inflammatory diseases of the gastrointestinal tract, collectively known as inflammatory bowel disease (IBD). Although the cause of IBD is still unclear, several experimental IBD murine models have enabled researchers to make great inroads into understanding human IBD pathology. Here, we discuss the current pre-clinical experimental murine models for human IBD, including the chemical-induced trinitrobenzene sulfonic acid (TNBS) model, oxazolone and dextran sulphate sodium (DSS) models, the gene-deficient I-kappa-B kinase gamma (Iκκ-γ) and interleukin(IL)-10 models, and the CD4+ T-cell transfer model. We offer a comprehensive review of how these models have been used to dissect the etiopathogenesis of disease, alongside their limitations. Furthermore, the way in which this knowledge has led to the translation of experimental findings into novel clinical therapeutics is also discussed

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Biosciences
Additional Information: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Publisher: MDPI
ISSN: 1422-0067
Date of First Compliant Deposit: 22 August 2022
Date of Acceptance: 17 August 2022
Last Modified: 10 Nov 2022 11:51
URI: https://orca.cardiff.ac.uk/id/eprint/152083

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