Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Inflammatory bowel disease: A review of pre-clinical murine models of human disease

Katsandegwaza, Brunette, Horsnell, William and Smith, Katherine ORCID: 2022. Inflammatory bowel disease: A review of pre-clinical murine models of human disease. International Journal of Molecular Sciences 23 (16) , 9344. 10.3390/ijms23169344

[thumbnail of ijms-23-09344-1.pdf]
PDF - Published Version
Available under License Creative Commons Attribution.

Download (2MB) | Preview


Crohn’s disease (CD) and ulcerative colitis (UC) are both highly inflammatory diseases of the gastrointestinal tract, collectively known as inflammatory bowel disease (IBD). Although the cause of IBD is still unclear, several experimental IBD murine models have enabled researchers to make great inroads into understanding human IBD pathology. Here, we discuss the current pre-clinical experimental murine models for human IBD, including the chemical-induced trinitrobenzene sulfonic acid (TNBS) model, oxazolone and dextran sulphate sodium (DSS) models, the gene-deficient I-kappa-B kinase gamma (Iκκ-γ) and interleukin(IL)-10 models, and the CD4+ T-cell transfer model. We offer a comprehensive review of how these models have been used to dissect the etiopathogenesis of disease, alongside their limitations. Furthermore, the way in which this knowledge has led to the translation of experimental findings into novel clinical therapeutics is also discussed

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Biosciences
Additional Information: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Publisher: MDPI
ISSN: 1422-0067
Date of First Compliant Deposit: 22 August 2022
Date of Acceptance: 17 August 2022
Last Modified: 10 Nov 2022 11:51

Citation Data

Cited 3 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item


Downloads per month over past year

View more statistics