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Synthesis and antimicrobial activity of 2,5-bis(Pyrazol-3-yl or Triazol-4-yl)-1,3,4-oxadiazoles

Mohamed, Hanan A., Abdel-Wahab, Bakr F., Sabry, Eman, Kariuki, Benson M. ORCID: and El-Hiti, Gamal A. ORCID: 2022. Synthesis and antimicrobial activity of 2,5-bis(Pyrazol-3-yl or Triazol-4-yl)-1,3,4-oxadiazoles. Heterocycles 104 (7) , pp. 1293-1302. 10.3987/COM-22-14676
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The reaction of pyrazole-3-carbohydrazide (1) or 1,2,3-triazole-4-carbohydrazides 5a,b and 2-(ethoxymethylene)malononitrile (2) in ethanol under reflux conditions afforded the corresponding N,N'-diacylhydrazines 3 or 6a,b, respectively in high yields. Ring closure of 3 or 6a,b in the presence of phosphorus oxychloride furnished the corresponding 2,5-bis(heterocyclic)-1,3,4-oxadiazoles 4 or 7a,b, respectively in good yields. The synthesized heterocyclic compounds showed moderate activity against Staphylococcus aureus, Listeria monocytogenes, and Escherichia coli.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Chemistry
Publisher: Elsevier
ISSN: 0385-5414
Date of First Compliant Deposit: 1 September 2022
Date of Acceptance: 12 May 2022
Last Modified: 10 Nov 2022 14:40

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