Infant limbus: an immunohistological study

Yeung, A.M., Tint, N.L., Kulkarni, B.B., Mohammed, Imran ORCID: https://orcid.org/0000-0002-8412-0768, Suleman, H., Hopkinson, Andrew and Dua, Harminder S. 2009. Infant limbus: an immunohistological study. Experimental Eye Research 88 (6) , pp. 1161-1164. 10.1016/j.exer.2008.12.014

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Abstract

All published literature to date has identified the human corneo-scleral limbus as the site within which stem cells of the ocular surface reside. Recently we described a unique anatomical structure at the limbus, termed the Limbal Epithelial Crypt (LEC) that has features of a putative stem cell niche. In this study we examined infant limbus tissue (donor age 4 months) for evidence of LEC and performed immunohistological comparison between infant limbus and adult LEC. No defined LEC were detected in the infant limbus. However, the entire infant limbus has characteristics resembling adult LEC. Both infant limbus and LEC demonstrated negative expression for desmoglein 3. p63 and integrin β1 expressions were located to the distal region of the infant limbus and to the basal region of the LEC. ABCG2 expression was positive throughout most of the infant limbus as was connexin 43. Infant limbus and in particular the distal region, appeared to house cells that are more “stem-like” in nature. The LEC may be a result of normal physiological developmental in order to protect and maintain stem cells at the ocular surface.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Optometry and Vision Sciences
ISSN:	0014-4835
Date of Acceptance:	29 December 2008
Last Modified:	11 Nov 2022 09:02
URI:	https://orca.cardiff.ac.uk/id/eprint/152709

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