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Editorial: Treatment of psychopathological and neurocognitive disorders in genetic syndromes: In need of multidisciplinary phenotyping and treatment design

Egger, Jos, Egger, Charlotte, Woodcock, Kate, De Witte, Lotje, Van Den Bree, Marianne ORCID: https://orcid.org/0000-0002-4426-3254, Van Dongen, Linde, Wingbermühle, Ellen and Kleefstra, Tjitske 2022. Editorial: Treatment of psychopathological and neurocognitive disorders in genetic syndromes: In need of multidisciplinary phenotyping and treatment design. Frontiers in Psychiatry 13 , 1009376. 10.3389/fpsyt.2022.1009376

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Abstract

Similar to the figures in a coloring book, which are set at the moment of printing, the framework for a new person is set the moment a human egg is fertilized. The genes that we are born with contribute to our vulnerability for a wide range of possible phenotypes, but which of these phenotypes will subsequently develop, is greatly influenced by contextual factors from the physical world and social environments we live in, and our lifestyles (e.g., nutrition and exercise). When looking at neurodevelopmental disorders with known genetic underpinnings, understanding the interaction between genes and context is vital for identification and support strategies. A fruitful way to achieve this would be through involvement of multiple disciplines, both in their additive capacities and in their ability to proceed from shared well-informed theoretical frameworks and clinical practice approaches. The inclusion of somatic, neuronal, cognitive and behavioral aspects, of rare genetic syndromes, and acquiring a more detailed understanding of altered brain development, new and fundamental insights can be gained, which can guide diagnosis and treatment decisions. In addition, a tailored approach to assessment and monitoring is necessary to understand how the contextual factors influence the (neuro)development of the individual patient under investigation. In the present Research Topic, nine studies have been brought together that illustrate ways to better assess the challenges that come with genetic neurodevelopmental disorders, to ameliorate symptoms, and in general to improve quality of life, not only of these individuals but also of their family members and other caregivers.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Additional Information: License information from Publisher: LICENSE 1: URL: http://creativecommons.org/licenses/by/4.0/
Publisher: Frontiers Media
Date of First Compliant Deposit: 20 September 2022
Date of Acceptance: 15 August 2022
Last Modified: 26 Oct 2022 14:04
URI: https://orca.cardiff.ac.uk/id/eprint/152739

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