Total synthesis of (+)-crocacin C

Dias, Luiz C. and Gonzaga De Oliveira, Luciana 2001. Total synthesis of (+)-crocacin C. Organic Letters 3 (24) , pp. 3951-3954. 10.1021/ol016845c

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Abstract

The total synthesis of (+)-crocacin C is described. The convergent asymmetric synthesis relies on the use of a regio- and diastereoselective epoxidation of an allylic alcohol with m-CPBA followed by epoxide opening with Me2CuCNLi2 and a Stille cross-coupling between E-vinyl stannane 5 and E-vinyl iodide 6 to establish the (E,E)-dienamide moiety.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Publisher:	American Chemical Society
ISSN:	1523-7060
Last Modified:	14 Nov 2022 16:04
URI:	https://orca.cardiff.ac.uk/id/eprint/153684

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