Dias, Luiz C. and Gonzaga De Oliveira, Luciana 2004. Short synthesis of the 6,6-spiroketal cores of spirofungins A and B. Organic Letters 6 (15) , pp. 2587-2590. 10.1021/ol0491078 |
Official URL: http://dx.doi.org/10.1021/ol0491078
Abstract
Initial efforts toward the total synthesis of the antifungal antibiotics spirofungins A and B are reported. A short and efficient synthesis of the C9−C20 6,6-spiroketal fragments of both compounds is described. This asymmetric approach uses a very efficient alkylation of a lithiated N,N-dimethylhydrazone followed by spiroketal formation under acidic conditions.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Chemistry |
Publisher: | American Chemical Society |
ISSN: | 1523-7060 |
Last Modified: | 14 Nov 2022 16:04 |
URI: | https://orca.cardiff.ac.uk/id/eprint/153686 |
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