Short synthesis of the 6,6-spiroketal cores of spirofungins A and B

Dias, Luiz C. and Gonzaga De Oliveira, Luciana 2004. Short synthesis of the 6,6-spiroketal cores of spirofungins A and B. Organic Letters 6 (15) , pp. 2587-2590. 10.1021/ol0491078

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Abstract

Initial efforts toward the total synthesis of the antifungal antibiotics spirofungins A and B are reported. A short and efficient synthesis of the C9−C20 6,6-spiroketal fragments of both compounds is described. This asymmetric approach uses a very efficient alkylation of a lithiated N,N-dimethylhydrazone followed by spiroketal formation under acidic conditions.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Publisher:	American Chemical Society
ISSN:	1523-7060
Last Modified:	14 Nov 2022 16:04
URI:	https://orca.cardiff.ac.uk/id/eprint/153686

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