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Total synthesis of the potent immunosuppressant (−)-Pironetin

Dias, Luiz C., Gonzaga De Oliveira, Luciana, Sousa, Márcio A. de, Ellensohn, Ricardo M. and Krapcho (editor), Paul 2005. Total synthesis of the potent immunosuppressant (−)-Pironetin. Arkivoc 2005 (6) , pp. 62-87. 10.3998/ark.5550190.0006.607

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A convergent and efficient total synthesis of (-)-pironetin, a compound that shows plant growth regulatory activity, and is immunosuppressive as well as having remarkable antitumoral activity, is described. The synthesis required 19 steps from N-propionyl oxazolidinone (S)-9 and produced the desired product in 11% overall yield. Keywords: Immunosuppressive activity.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Chemistry
ISSN: 1424-6376
Date of Acceptance: 12 April 2005
Last Modified: 14 Nov 2022 16:05

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