Nature-inspired enzymatic cascades to build valuable compounds

Sigrist, Renata, Costa, Bruna Zucoloto da, Marsaioli, Anita Jocelyne and Gonzaga De Oliveira, Luciana 2015. Nature-inspired enzymatic cascades to build valuable compounds. Biotechnology Advances 33 (5) , pp. 394-411. 10.1016/j.biotechadv.2015.03.010

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Abstract

Biocatalysis currently is focusing on enzymatic and multi-enzymatic cascade processes instead of single steps imbedded into chemical pathways. Alongside this scientific revolution, this review provides an overview on multi-enzymatic cascades that are responsible for the biosynthesis of some terpenes, alkaloids and polyethers, which are important classes of natural products. Herein, we illustrate the development of studies inspired by multi- and chemo-enzymatic approaches to build the core moieties of polyethers, polypeptide alkaloids, piperidines and pyrrolidines promoted by the joint action of oxidoreductases, hydrolases, cyclases, transaminases and imine reductases.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Publisher:	Elsevier
ISSN:	0734-9750
Last Modified:	14 Nov 2022 16:05
URI:	https://orca.cardiff.ac.uk/id/eprint/153704

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