Genome mining of endophytic Streptomyces wadayamensis reveals high antibiotic production capability

Angolini, Célio F. F., Gonçalves, Ana B., Sigrist, Renata, Paulo, Bruno S., Samborskyy, Markiyan, Cruz, Pedro L. R., Vivian, Adriana F., Schmidt, Eduardo M., Eberlin, Marcos N., Araújo, Welington L. and Gonzaga De Oliveira, Luciana 2016. Genome mining of endophytic Streptomyces wadayamensis reveals high antibiotic production capability. Journal of the Brazilian Chemical Society 27 (8) , pp. 1465-1475. 10.5935/0103-5053.20160180

Full text not available from this repository.

Abstract

The actinobacteria Streptomyces wadayamensis A23, an endophitic strain, was recently sequenced and previous work showed qualitatively that the strain inhibits the growth of some pathogens. Herein we report the genome analysis of S. wadayamensis which reveals several antibiotic biosynthetic pathways. Using mass spectrometry, we were able to identify desferoxamines, several antimycins and candicidin, as predicted. Additionally, it was possible to confirm that the biosynthetic machinery of the strain when compared to identified known metabolites is far underestimated. As suggested by biochemical qualitative tests, genome encoded information reveals that the strain A23 has high capability to produce antibiotics.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Chemistry
Publisher:	Sociedade Brasileira de Química, SBQ
ISSN:	0103-5053
Last Modified:	14 Nov 2022 16:05
URI:	https://orca.cardiff.ac.uk/id/eprint/153707

Citation Data

Cited 6 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item