Avanços recentes em biossíntese combinatória de policetídeos: perspectivas e desafios Recent advances in combinatorial biosynthesis of polyketides: perspectives and challenges

Paulo, Bruno, Sigrist, Renata and Gonzaga De Oliveira, Luciana 2018. Avanços recentes em biossíntese combinatória de policetídeos: perspectivas e desafios Recent advances in combinatorial biosynthesis of polyketides: perspectives and challenges. Química Nova 42 (1) , pp. 71-83. 10.21577/0100-4042.20170307

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Abstract

Natural products continue to inspire scientists on the search for biological active structures. Recent advances in synthetic biology allow modifying genes to extend structural diversity present on natural products by changing important functional groups guided through genetic information. In this context, polyketides synthases (PKS) represent a class of enzymes from where the first applications and well succeed modifications were achieved. During the last two decades PKSs have been extensively studied, sequenced and deposited in data banks available to scientific community around the world. This newly wide information associated to different methodologies accessible to modify the PKSs genetic circuits including genetic insertion, gene deletion and gene replacement leads to discovery of new natural products. In this review, the recent advances in combinatorial biosynthesis, as well as modern techniques in synthetic biology to promote structural diversity on natural products will be discussed.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Chemistry
Additional Information:	This is an open-access article distributed under the terms of the Creative Commons Attribution License.
Publisher:	SOC BRASILEIRA QUIMICA
ISSN:	0100-4042
Date of First Compliant Deposit:	9 November 2022
Date of Acceptance:	23 October 2018
Last Modified:	23 May 2023 14:28
URI:	https://orca.cardiff.ac.uk/id/eprint/153708

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