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Cognitive processes of apathy in Huntington's Disease show high sensitivity to disease progression

Hare, Emily, Bachoud-Lévi, Anne-Catherine, Reilmann, Ralf, Craufurd, David, Busse, Monica ORCID:, Rosser, Anne ORCID: and McLauchlan, Duncan 2022. Cognitive processes of apathy in Huntington's Disease show high sensitivity to disease progression. Clinical Parkinsonism & Related Disorders 7 , 100168. 10.1016/j.prdoa.2022.100168

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Background Disease-modifying treatments for Huntington’s disease (HD) are entering clinical trials: there is a pressing need for objective outcome measures of disease progression. Our previous work showed an association between 2 novel, objective cognitive tasks and apathy - a core feature of disease progression in HD. Objective Evaluate the longitudinal validity and sensitivity of the novel Persistence and Maze tasks to assess their utility as clinical outcome measures in HD. Methods 83 participants positive for the HD gene and 54 controls performed a battery of established and novel tools, at baseline and 12 month follow up. Results The Maze task was found to be the most sensitive measure of change at 12 months, including the current gold-standard measure (the composite disease progression score). Conclusion The Maze task has potential as a novel outcome measure of disease progression in HD and may have utility in other major neurodegenerative diseases.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Centre for Trials Research (CNTRR)
Publisher: Elsevier
ISSN: 2590-1125
Funders: MRC
Date of First Compliant Deposit: 1 November 2022
Date of Acceptance: 18 October 2022
Last Modified: 18 Nov 2023 18:10

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