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Cognitive and neuropsychiatric impairment in dystonia

Bailey, Grace A., Martin, Eva and Peall, Kathryn J. ORCID: 2022. Cognitive and neuropsychiatric impairment in dystonia. Current Neurology and Neuroscience Reports 22 , pp. 699-708. 10.1007/s11910-022-01233-3

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Purpose of Review To review recent literature evaluating psychiatric and cognitive symptoms in dystonia, the two non-motor symptom groups most frequently evaluated in dystonia research and recognised in clinical practice. Recent Findings Recent work has embedded clinical recognition of psychiatric symptoms in dystonia, with depressive and anxiety-related symptoms routinely observed to be the most common. Less explored symptoms, such as self-harm, suicidal ideation, and substance abuse, represent newer areas of investigation, with initial work suggesting higher rates than the background population. Investigation of cognitive function has provided less consistent results, both within individual dystonia subtypes and across the spectrum of dystonias, partly reflecting the heterogeneity in approaches to assessment. However, recent work indicates impairments of higher cognitive function, e.g. social cognition, and disrupted visual and auditory sensory processing. Summary Dystonia demonstrates psychiatric and cognitive symptom heterogeneity, with further work needed to recognise endophenotypes and improve diagnostic accuracy, symptom recognition, and management.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Publisher: Springer
ISSN: 1528-4042
Funders: MRC
Date of First Compliant Deposit: 2 November 2022
Date of Acceptance: 12 September 2022
Last Modified: 28 Feb 2024 10:34

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